INDICATORS ON SIK YOU SHOULD KNOW

The purpose of SIK1 in tumorigenesis. SIK1 is a tumor suppressor gene, which plays a vital regulatory role in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may also endorse cancer cell anoik